Publications – Guha Labs

Articles and reviews

* Corresponding author

# equal contribution

2026

Chatterjee S, Sin Z, Van RA, Tran N, Tran T, Shukla A, Jeusset LMP, Koshkaryan G, Saldana K, Muneer R, Viera Preval L, Gu L, Bhat F, Ritter K, Huang K, Huff-Hardy K, Rood R, Gremida A, Gregory M, Chen CH, Weng M, Dekker FJ, Deepak P, Jessen HJ, McManus KJ, Han MV, Guha P*. Fasting disrupts the InsP6 HDAC3 axis to drive ER stress-mediated clearance of DNA-damaged cells and enforce tissue quality control. bioRxiv. 2026. doi: 10.64898/2026.05.24.727426.

Chatterjee S, Sin Z, Tran N, Vierra L, Shukla A, Tran T, Koshkaryan G, Ritter K, Su XB, Ragsac SJ, Park S, Liu Q, Van R, Huang K, Huff-Hardy K, Rood R, Gremida A, Gregory M, Chen CH, Han MV, Deepak P, Saiardi A, Jessen HJ, Guha P*. (2026). Phytic acid (InsP(6)) activates HDAC3 epigenetic axis to maintain intestinal barrier function. Nat Commun. 2026 Feb 9;. doi: 10.1038/s41467-026-68994-0.

2025

Mishra SH, Chatterjee S, Viera-Preval L, Guha P*. From Obscurity to Prominence: IPMK’s Expanding Role in Cellular Signaling, Physiology, and Disease. Biomolecules. 2025 Sep 1;15(9). doi: 10.3390/biom15091266.

Chatterjee S, Ghosh S, Sin Z, Babu VS, Preval LV, Davis E, Tran N, Bammidi S, Gautam P, Hose S, Sergeev Y, Flores-Bellver M, Ritter K, Jessen HJ, Al Diri I, Sinha D, Guha P*. Age-Dependent Histone Deacetylase 3 Regulation by βA3/A1-Crystallin and Inositol Hexaphosphate in Retinal Pigmented Epithelial Cells Reveals a Novel Pathway in Age-Related Macular Degeneration. Aging Cell. 2025 Sep;24(9):e70163. doi: 10.1111/acel.70163.

Isaac I, Patel L, Tran N, Singam A, Yun D, Guha P, Park S, Bhattacharya C*. Reengineering Endogenous Targeting Lipid Nanoparticles (ENDO) for Systemic Delivery of mRNA to Pancreas. Adv Mater. 2025 Oct;37(40):e2507657. doi: 10.1002/adma.202507657.

Doshi R, Kinnear E, Chatterjee S, Guha P, Liu Q*. Reliable investigation of DNA methylation using Oxford nanopore technologies. Sci Rep. 2025 May 7;15(1):15900. doi: 10.1038/s41598-025-99882-0.

Sin Z, Kinnear E, Doshi R, Chatterjee S, Derbel H, Guha P*, Liu Q*. IPMK depletion influences genome-wide DNA methylation. Biochem Biophys Res Commun. 2025 Jun 20;766:151874. doi: 10.1016/j.bbrc.2025.151874.

Chowdhury O, Bammidi S, Gautam P, Babu VS, Liu H, Shang P, Xin Y, Mahally E, Nemani M, Koontz V, Lathrop K, Kedziora KM, Franks J, Sun M, Smith JW, DeVine LR, Cole RN, Stepicheva N, Strizhakova A, Chattopadhyay S, Hose S, Zigler JS Jr, Sahel JA, Qian J, Guha P, Handa JT, Ghosh S, Sinha D. Activated mTOR Signaling in the RPE Drives EMT, Autophagy, and Metabolic Disruption, Resulting in AMD-Like Pathology in Mice. Aging Cell. 2025 Jun;24(6):e70018. doi: 10.1111/acel.70018.

2024

Chetterjee S, Viera- Preval L, Sin Z, Tran , Ritter K, Su XB, Centlivre JP, Ragsac J, Van R, Park S, Han MV, Liu Q, Hedlund BP, Saiardi A, Jessen HJ, Guha P*. Inositol Hexaphosphate (InsP6) Activates the HDAC1/3 Epigenetic Axis to Maintain Intestinal Barrier Function. bioRxiv. 2024 September. doi: https://doi.org/10.1101/2024.09.15.613154.

Park S, Laskow TC, Chen J, Guha P, Dawn B, Kim DH. Microphysiological systems for human aging research. Aging Cell. 2024 Mar;23(3):e14070. doi: 10.1111/acel.14070.

2023

Reilly L, Semenza ER, Koshkaryan G, Mishra S, Chatterjee S, Abramson E, Mishra P, Sei Y, Wank SA, Donowitz M, Snyder SH, Guha P*. (2023). Loss of PI3k activity of inositol polyphosphate multikinase impairs PDK1-mediated AKT activation, cell migration, and intestinal homeostasis.iScience,2023 Apr 11;26(5):106623. doi: 10.1016/j.isci.2023.106623.

2021

Guha P*, Reilly L, Semenza E, Abramson E, Mishra S, Sei Y, Wank S A, Donowitz M, and Snyder S.H.* . (2020) Loss of PI3-Kinase Activity of Inositol Polyphosphate Multikinase Impairs PDK1 Mediated AKT Activation, and Intestinal Epithelial Cell Renewal. bioRxiv.

2020

Harraz M. M* #, Guha P* #, Kang I, Malla A, Song Y, Reilly L, Treisman I, Cortes P, oggiano M, Veeravalli V, Rais R, Tanda G, Snyder S.H. (2021). Cocaine-induced locomotor stimulation involves autophagic degradation of the dopamine transporter. Mol Psychiatry, 26, 1-13.

2019

Guha P*, & Snyder, S. H* . (2019). Noncatalytic functions of IPMK are essential for activation of autophagy and liver regeneration. Autophagy, 15(8), 1473-1474.

Guha, P., Tyagi, R., Chowdhury, S., Reilly, L., Fu, C., Xu, R., . . . Snyder, S. H. (2019). IPMK mediates activation of ULK signaling and transcriptional regulation of autophagy linked to liver inflammation and regeneration. Cell Reports, 26(10), 2692-2703.

2018

Fu, C., Tyagi, R., Chin, A. C., Rojas, T., Li, R. J., Guha, P., . . . Snyder, S. H. (2018). Inositol polyphosphate multikinase inhibits angiogenesis via inositol pentakisphosphate-induced HIF-1alpha degradation. Circulation Research, 122(3), 457-472.

2017

Guha, P., Kaptan, E., Gade, P., Kalvakolanu, D. V., & Ahmed, H. (2017). Tunicamycin induced endoplasmic reticulum stress promotes apoptosis of prostate cancer cells by activating mTORC1. Oncotarget, 8(40), 68191-68207.

2016

Guha, P#., Harraz, M. M#., & Snyder, S. H. (2016). Cocaine elicits autophagic cytotoxicity via a nitric oxide-GAPDH signaling cascade. Proceedings of the National Academy of Sciences of the United States of America, 113(5), 1417-1422.

2014

Guha, P., Bandyopadhyaya, G., Polumuri, S. K., Chumsri, S., Gade, P., Kalvakolanu, D. V., & Ahmed, H. (2014). Nicotine promotes apoptosis resistance of breast cancer cells and enrichment of side population cells with cancer stem cell-like properties via a signaling cascade involving galectin-3, alpha9 nicotinic acetylcholine receptor and STAT3. Breast Cancer Research and Treatment, 145(1), 5-22.

2013

Guha, P., Kaptan, E., Bandyopadhyaya, G., Kaczanowska, S., Davila, E., Thompson, K., . . . Ahmed, H. (2013). Cod glycopeptide with picomolar affinity to galectin-3 suppresses T-cell apoptosis and prostate cancer metastasis. Proceedings of the National Academy of Sciences of the United States of America, 110(13), 5052-5057.

Xu, R., Paul, B. D., Smith, D. R., Tyagi, R., Rao, F., Khan, A. B., Guha, P. .. Snyder, S. H. (2013). Inositol polyphosphate multikinase is a transcriptional coactivator required for immediate early gene induction. Proceedings of the National Academy of Sciences of the United States of America, 110(40), 16181-16186.

2012

Vasta, G. R., Ahmed, H., Nita-Lazar, M., Banerjee, A., Pasek, M., Shridhar, S., Guha, P. . . Fernandez-Robledo, J. A. (2012). Galectins as self/non-self-recognition receptors in innate and adaptive immunity: An unresolved paradox. Frontiers in Immunology, 3, 199.

Jayanta K Sarmah, Rita Mahanta,……… Prasun Guha, Angshuman Biswas. (2012).
In-vitro cytotoxicity analysis of tamoxifen citrate loaded cross-linked guar gum nanoparticles on jurkat (human t-cell leukemia) cell line. Journal of Drug Delivery and Therapeutics. 2(2).

2011

Ahmed, H., Guha, P., Kaptan, E., & Bandyopadhyaya, G. (2011). Galectin-3: A potential target for cancer prevention. Trends in Carbohydrate Research, 3(2), 13-22.

Guha, P., Dey, A., Sen, R., Chatterjee, M., Chattopadhyay, S., & Bandyopadhyay, S. K. (2011). Intracellular GSH depletion triggered mitochondrial bax translocation to accomplish resveratrol-induced apoptosis in the U937 cell line. The Journal of Pharmacology and Experimental Therapeutics, 336(1), 206-214.

Guha, P., Dey, A., Chattopadhyay, S., & Bandyopadhyay, S. K. (2011) French paradox and apoptosis: the journey of a phytoalexin, resveratrol. Journal of Nutritional Therapy and Metabolism. 2011.29: 2.

2010

Guha, P., Dey, A., Dhyani, M. V., Sen, R., Chatterjee, M., Chattopadhyay, S., & Bandyopadhyay, S. K. (2010). Calpain and caspase orchestrated death signal to accomplish apoptosis induced by resveratrol and its novel analog hydroxystilbene-1 [correction of hydroxstilbene-1] in cancer cells. The Journal of Pharmacology and Experimental Therapeutics, 334(2), 381-394.

P Guha, A Dey, A Chatterjee, S Chattopadhyay and SK Bandyopadhyay (2010). Pro-ulcer effects of resveratrol in mice with indomethacin-induced gastric ulcers are reversed by L-arginine. British Journal of Pharmacology, 159: 726–734.

2009

Dey, A., Guha, P., Chattopadhyay, S., & Bandyopadhyay, S. K. (2009). Biphasic activity of resveratrol on indomethacin-induced gastric ulcers. Biochemical and Biophysical Research Communications, 381(1), 90-95.

Guha, P., Dey, A., Sarkar, B., Dhyani, M. V., Chattopadhyay, S., & Bandyopadhyay, S. K. (2009). Improved antiulcer and anticancer properties of a trans-resveratrol analog in mice. The Journal of Pharmacology and Experimental Therapeutics, 328(3), 829-838.

Bandyopadhyay, S. K., Chattopadhyay, S., Guha P*, Dey, A*., (2009). Anticancer power of Resveratrol. Herbication (HFP-06).

2008

N. Majumder, S. Bhattacharjee, S. Bhattacharyya (Majumdar), R. Dey, Guha P, N. K. Pal S. Majumdar (2008). Restoration of Impaired Free Radical Generation and Proinflammatory Cytokines by MCP-1 in Mycobacterial Pathogenesis. Scand. J. Immunol. 67, 329-339.

2006

B Halder, Guha P, S Pramanick, S Mukhopadhyay and Ak Giri (2006). Antimutagenic effects of fractions of thearubigins of black tea in salmonella assay. Nucleus. 49 (3): 145-154.

Professional services to journals

Invited peer reviewer

PNAS, Autophagy, Cells, Biomedicine, Cancers, Cells etc